Curcumin Inhibits the PERK-eIF2<i>α</i>-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model

<div>EX527 abrogated the protective of curcumin in TBHP-stimulated rat chondrocytes by inhibiting the PERK-eIF2<i>α</i>-CHOP pathway. (a, c) Immunofluorescence staining of SIRT1 (bar: 10 <i>μ</i>m). The fluorescence intensity of SIRT1 was analyzed by ImageJ. (b, d) The expression of SIRT1 and PERK-eIF2<i>α</i>-CHOP pathway-related proteins was assessed after the treatment of EX527 by western blotting analysis. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Curcumin Inhibits the PERK-eIF2<i>α</i>-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model 

Figure 6 | Curcumin Inhibits the PERK-eIF2α-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model 