Oleuropein-Induced Apoptosis Is Mediated by Mitochondrial Glyoxalase 2 in NSCLC A549 Cells: A Mechanistic Inside and a Possible Novel Nonenzymatic Role for an Ancient Enzyme

<div>Oleuropein induces apoptosis in NSCLC A549 cells through mitochondrial glyoxalase 2 (Glo2). Oleuropein induces (→) SOD2 upregulation and consequent scavenging (<b>⊣</b>) of superoxide anion O<sub>2</sub><sup>⋅-</sup>. The depletion of O<sub>2</sub><sup>⋅-</sup> inhibits (<b>⊣</b>) the Akt signaling pathway that, in turn, induces (→) the upregulation of mitochondrial Glo2 expression. Glo2 interacts with the proapoptotic protein Bax activating apoptosis through the intrinsic pathway [cytochrome c (Cyt c) release from the mitochondrion, activation of Apaf-1, and eventually caspase-3 activation].</div>

Oxidative Medicine and Cellular Longevity

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Figure 6

Figure 6: Oleuropein-Induced Apoptosis Is Mediated by Mitochondrial Glyoxalase 2 in NSCLC A549 Cells: A Mechanistic Inside and a Possible Novel Nonenzymatic Role for an Ancient Enzyme 

Figure 6 | Oleuropein-Induced Apoptosis Is Mediated by Mitochondrial Glyoxalase 2 in NSCLC A549 Cells: A Mechanistic Inside and a Possible Novel Nonenzymatic Role for an Ancient Enzyme 