Euphorbia bicolor (Euphorbiaceae) Latex Extract Reduces Inflammatory Cytokines and Oxidative Stress in a Rat Model of Orofacial Pain
Total polyphenolic contents, in vitro antioxidant, in vitro free radical scavenging activities, and IC50 values of E. bicolor latex extract. Total phenolic (TPC), flavonoid (TFC), proanthocyanidin (TPrC), and terpenoid (TTC) contents of latex extract (a). Asterisks indicate significance compared to TFC at by one-way ANOVA with Tukey’s analysis. Reducing power (b), percent inhibition of the 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical (c), percent inhibition of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical (d), percent inhibition of the hydrogen peroxide (H2O2) radical (e), and percent inhibition of the nitric oxide (NO) radical (f). For each assay, extract (black bars) was compared to its corresponding standard (grey bars) by two-way ANOVA with Bonferroni post hoc analysis at . Significant difference compared to the positive control. IC50 values of radical scavenging activities of latex extract (g). Asterisks indicate significance compared to IC50 of DPPH scavenging activity at by one-way ANOVA with Tukey’s analysis.
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