Review Article
Relationship of Oxidative Stress as a Link between Diabetes Mellitus and Major Depressive Disorder
Table 1
Summary of changes associated to oxidative stress in diabetes mellitus and major depressive disorder.
| Species/model | Damage | Antioxidant effect | Reference |
| Alloxan-diabetic rats | Depressive behavior | N-Acetylcysteine and imipramine displayed antidepressant effects | [48, 49] | Diabetic rats | Depressive behavior and oxidative stress | Clonazepam and insulin reversed the depressive behavior and restored the antioxidant status | [50, 52] | STZ-diabetic rats | Depressive behavior | Hydrogen sulfide induced antidepressant effects | [53] | STZ-diabetic rats | Depressive behavior, oxidative stress, and inflammation | Metformin plus ascorbic acid reduced the depressive behavior and had antioxidant and anti-inflammatory effects | [54] | STZ-nicotinamide-diabetic rats | Depressive behavior | Ascorbic acid had antidepressant effects, reduced oxidative stress, and inflammation | [55, 56] | STZ-diabetic rats | Depressive behavior | Aloe vera displayed antidepressant, antioxidant, and antidiabetic effects | [56] | MDD and bipolar disorder patients | Severity of symptoms was associated to glucose levels and the number of episodes to glucose toxicity | ā | [63] |
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