Plin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally

Figure 5

The role of oxidative stress induced by disruption of Plin5 balance in CMECs under the condition of HG-HFFAs. (a, d) ROS in CMECs detected by DHE staining. (b, e) The statistics of apoptosis rate. (c, f) The NO generation in CMECs. ROS: reactive oxygen species; DHE: dihydroethidium; NAC: N-acetyl-cysteine; Vel: vehicle; ISO: isoproterenol; HG-HFFAs: high glucose and high free fatty acid. Data are expressed as , /group. , vs. WT+Vel; ^# vs. Plin5^-/-+Vel; ^&, ^&& vs. Vel; ^@, ^@@ vs. ISO.

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