Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 7

Research Article

Overexpression of BRCA1 in Neural Stem Cells Enhances Cell Survival and Functional Recovery after Transplantation into Experimental Ischemic Stroke

Figure 7

Modification with BRCA1 enhanced neurotropic factor expression, increased grafted cell survival, and improved neurobehavioral performance. (a, b) Western blot and quantitative analysis of BDNF and NGF in injured brain tissue 2 d after transplantation. mice/group. (c) Representative images of GFP-positive NSCs that survived 28 d after stroke. Scale bar: 50 μm. (d) Quantification of the number of surviving grafted cells. mice/group. (e, f) The mNSS and adhesive-removal test were performed in MCAO mice. mice/group. Data are expressed as ; , , and vs. the PBS-injected mice; , , and vs. the LV-GFP NSCs-implanted mice.