Overexpression of BRCA1 in Neural Stem Cells Enhances Cell Survival and Functional Recovery after Transplantation into Experimental Ischemic Stroke
Modification with BRCA1 enhanced neurotropic factor expression, increased grafted cell survival, and improved neurobehavioral performance. (a, b) Western blot and quantitative analysis of BDNF and NGF in injured brain tissue 2 d after transplantation. mice/group. (c) Representative images of GFP-positive NSCs that survived 28 d after stroke. Scale bar: 50 μm. (d) Quantification of the number of surviving grafted cells. mice/group. (e, f) The mNSS and adhesive-removal test were performed in MCAO mice. mice/group. Data are expressed as ;,, and vs. the PBS-injected mice; ,, and vs. the LV-GFP NSCs-implanted mice.