Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer

Figure 1

p53 is positively related to pyroptosis in the tumor tissue of NSCLC patients. (a–d) mRNA levels of NLRP3, ASC, caspase-1, and cleaved caspase-1 were detected by real-time PCR and analyzed by SPSS. Wild-type p53 mRNA level shows a positive correlation with NLRP3, ASC, and cleaved caspase-1 in tumor tissues of 20 NSCLC patients. (e) p53 protein level (upper panel) and NLRP3 (lower panel) expression were determined by DAB staining. Arrows represent DAB-positive staining area. Scale bar equals 50 μm.

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