Transcription Factor p53 Suppresses Tumor Growth by Prompting Pyroptosis in Non-Small-Cell Lung Cancer

Figure 5

p53-activated pyroptosis inhibits the development of NSCLC in tumor-bearing mice. (a) mRNA levels were measured in the control and p53 overexpression groups. Control mice were transplanted with A549 cells transfected with pcDNA3.1 vector. The p53 overexpression group was induced with transplantation with A549 cells transfected with p53 overexpression vector. Tumor tissues were extracted after mice death or 8 weeks of feeding; in each group. The data are presented as the ; versus the control group. (b–d) Tumor size, weight, and volume were measured in each group; , , , . (e) Survival percentage was calculated throughout 8-week feeding.

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