Ferritinophagic Flux Activation in CT26 Cells Contributed to EMT Inhibition Induced by a Novel Iron Chelator, DpdtpA

Figure 8

DpdtpA induced ferritinophagy in the presence of TGF-β1. The nuclei stained by DAPI in blue, NCOA4 in green, and ferritin in red. (a-d) (0.7% DMSO, TGF-β1 treatment only): (a) nuclei in blue; (b) NCOA4 in green; (c) ferritin in red; (d) merge of nuclei, ferritin, and NCOA4. (e)-(h) TGF-β1 combined with DpdtpA: (e) nuclei in blue; (f) NCOA4 in green; (g) ferritin in red; (h) merge of nuclei, ferritin, and NCOA4. Objective size: , scale bar: 100 μm. The measurements were performed thrice from different field of view.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)