SIRT1 Modulators in Experimentally Induced Liver Injury

Figure 1

Effects of resveratrol and EX-527 pretreatment in lipopolysaccharide-induced acute hepatitis in D-galactosamine-sensitized rats (D-GalN/LPS) on the levels of (a) plasma ALT, (b) TBARS in homogenate and (c) SIRT1 expression. CO: control group; RES: 2.3 mg/kg resveratrol; D-: 400 mg/kg D-galactosamine with 10 μg/kg lipopolysaccharide; -: 2.3 mg/kg -; -: 1 mg/kg EX-527 plus a combination of previous substances. Data are expressed as (). versus CO. versus RES. versus D-. versus - (courtesy of Physiological Research, reference [140]).

(a) ALT

(b) TBARS

(c) SIRT1 protein expression