Sargassum fusiforme Fucoidan SP2 Extends the Lifespan of Drosophila melanogaster by Upregulating the Nrf2-Mediated Antioxidant Signaling Pathway

Figure 1

Antioxidant capacity of the different polysaccharides fractionated from SFPS. Antioxidant activity of the polysaccharides was assayed in three different cell-free systems. (a) DPPH-scavenging activity, (b) ABTS-scavenging activity, and (c) radical-scavenging activities and Fe²⁺ reducing. Data are shown as from three determinations. “,” “,” and “” indicate a significant difference at the , , and levels, respectively. (d) Fruit flies were randomly collected (100 flies/group) and reared on basal medium without (control group) or with 1.6 g/L of SP1, SP2, or SP3 for 10 days. Subsequently, the in vivo oxidative resistant capacity was evaluated by determining the survival rate of the flies following exposure to oxidative stress induced by 5 mmol/L paraquat, given as a diet.

(a)

(b)

(c)

(d)