Research Article
Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss
Table 1
Trabecular microarchitecture and biochemical markers of LPS with or without lycorine-treated mice.
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PBS (); LPS (dissolved in PBS, 5 mg/kg) (); LPS+lycorine (dissolved in PBS, 6 mg/kg) (); lycorine (). Data are represented as . Differences between groups were analyzed by two-way ANOVA, followed by Bonferroni posttests to compare the effect of lycorine (BMD, ; Tb.Th, ; BV/TV and CTX-1, ) and the effect of LPS (MCP-1, ; BMD, Tb.Th, Tb.Sp, and CTX-1, ) and interaction (BV/TV, Tb.Th, Tb.Sp, and MCP-1, ; BMD, ; CTX-1, ). a and a compared with vehicle-injected mice. b, b, and b compared with LPS-injected mice. |