Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling

Figure 3

Effects of SAC on liver lipid peroxides (a) and GSH (b) levels and on serum NO (c), TNF-α (d), IL-1β (e), and IL-6 (f) levels in APAP-induced mice. Mice were given PBS alone or SAC (5, 10, and 20 mg/kg body weight) via intraperitoneal injection 1 h before challenge with APAP (400 mg/kg). Mice were killed at 12 h after APAP challenge, and the liver and serum were harvested. GSH was determined and expressed as μmol/g liver tissues. Nitrite concentration in the serum was determined using Griess reagent. Serum concentrations of TNF-α, IL-1β, and IL-6 were determined by the commercial ELISA kits. The values are reported as the .E.M. of five mice per group. compared with the control group; , , and compared with the APAP group.

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