Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling

Figure 4

SAC inhibited iNOS, COX-2 (a), IκBα, NF-κB (b), TLR4 (c), and MAPK (d) expression in APAP-induced mice. Total protein was extracted from liver tissues, and the protein levels of iNOS, COX-2, IκB-α, NF-κB, TLR4, p-JNK, JNK, p-ERK, ERK, p-p38, and p-38 were determined by Western blot analysis. β-Actin served as a loading control. The values are reported as the .E.M. of five mice per group. compared with the control group; , , and compared with the APAP group.

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