Research Article
Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer’s Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway
Figure 4
KXS inhibited hyperphosphorylation of Tau by activating the PI3K/Akt/GSK-3β signaling pathway. KXS upregulated the PI3K/Akt signaling pathway, restored the phosphorylation activity of GSK-3β (Ser9), and decreased the degree of Tau phosphorylation caused by Aβ25-35 and D-gal. Representative western images (a) and quantification (b) of protein related to the Tau signaling pathway in the rat hippocampus were represented. The area fraction of the hippocampus occupied by p-Tau (S396) was calculated using Image-Pro Plus software (c and d). Values were the (). vs. the control group; #, ##, and ### vs. the model group; $ and $$ vs. the Hup A group. .
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