Oxidative Medicine and Cellular Longevity / 2019 / Article / Tab 4 / Research Article
Tocotrienol-Rich Fraction (TRF) Treatment Promotes Proliferation Capacity of Stress-Induced Premature Senescence Myoblasts and Modulates the Renewal of Satellite Cells: Microarray Analysis Table 4 KEGG pathway analysis regulated by the TRF-posttreated SIPS cells as compared to the SIPS control (
according to the (a) differential expression of gene and (b) pathway ANOVA analysis.
(a)
KEGG entry Pathway NES hsa04110 Cell cycle 25.93 5.50E − 12 hsa03030 DNA replication 20.99 7.64E − 10 hsa04115 p53 signalling pathway 16.76 5.25E − 08 hsa05206 MicroRNAs in cancer 16.08 1.03E − 07 hsa03460 Fanconi anemia pathway 14.93 3.29E − 07 hsa05203 Viral carcinogenesis 14.45 5.30E − 07 hsa05200 Pathways in cancer 12.88 2.54E − 06 hsa03430 Mismatch repair 10.17 3.81E − 05 hsa05322 Systemic lupus erythematosus 10.00 4.53E − 05 hsa04114 Oocyte meiosis 9.11 1.11E − 04 hsa05034 Alcoholism 8.64 1.76E − 04 hsa03420 Nucleotide excision repair 7.96 3.50E − 04 hsa03440 Homologous recombination 6.78 1.13E − 03 hsa00900 Terpenoid backbone biosynthesis 6.72 1.21E − 03 hsa05219 Bladder cancer 6.38 1.70E − 03 hsa05166 HTLV-I infection 6.16 2.11E − 03 hsa00310 Lysine degradation 6.02 2.43E − 03 hsa05210 Colorectal cancer 5.56 3.86E − 03 hsa04914 Progesterone-mediated oocyte maturation 5.20 5.52E − 03 hsa04068 FoxO signalling pathway 5.10 6.10E − 03 hsa05205 Proteoglycans in cancer 4.75 8.61E − 03 hsa04978 Mineral absorption 4.50 1.11E − 02 hsa04390 Hippo signalling pathway 4.49 1.12E − 02 hsa05222 Small cell lung cancer 4.23 1.46E − 02 hsa05217 Basal cell carcinoma 4.06 1.72E − 02 hsa05212 Pancreatic cancer 4.04 1.76E − 02 hsa00480 Glutathione metabolism 3.40 3.34E − 02 hsa05214 Glioma 3.17 4.22E − 02 hsa04310 Wnt signalling pathway 3.16 4.25E − 02
(b)
KEGG entry Pathway Fold change hsa05323 Rheumatoid arthritis 8.98E − 03 1.13 hsa04630 Jak-STAT signalling pathway 1.12E − 02 1.07 hsa04978 Mineral absorption 1.56E − 02 1.13 hsa00860 Porphyrin and chlorophyll metabolism 1.89E − 02 1.14 hsa04340 Hedgehog signalling pathway 1.93E − 02 1.10 hsa00520 Amino sugar and nucleotide sugar metabolism 2.06E − 02 1.11 hsa05217 Basal cell carcinoma 2.12E − 02 1.10 hsa00561 Glycerolipid metabolism 2.18E − 02 1.09 hsa00630 Glyoxylate and dicarboxylate metabolism 2.20E − 02 −1.16 hsa04330 Notch signalling pathway 2.22E − 02 1.08 hsa00564 Glycerophospholipid metabolism 2.33E − 02 1.07 hsa00100 Steroid biosynthesis 2.46E − 02 −1.20 hsa00040 Pentose and glucuronate interconversions 2.66E − 02 1.16 hsa00051 Fructose and mannose metabolism 2.76E − 02 1.10 hsa03050 Proteasome 2.79E − 01 1.11 hsa00980 Metabolism of xenobiotics by cytochrome P450 3.08E − 02 1.08 hsa00650 Butanoate metabolism 3.11E − 02 −1.13 hsa00052 Galactose metabolism 3.13E − 02 1.12 hsa04640 Hematopoeitic cell lineage 3.22E − 02 1.08 hsa03060 Protein export 3.34E − 02 1.13 hsa04130 SNARE interactions in vesicular transport 3.35E − 02 1.08 hsa04110 Cell cycle 3.39E − 02 −1.31 hsa04966 Collecting duct acid secretion 3.48E − 02 1.23 hsa03430 Mismatch repair 3.68E − 02 −1.38 hsa03030 DNA replication 3.70E − 02 −1.80 hsa03460 Fanconi anemia pathway 3.79E − 02 −1.29 hsa00533 Glycosaminoglycan biosynthesis-keratan sulfate 3.99E − 02 1.12 hsa04012 ErbB signalling pathway 4.04E − 02 1.05 hsa03450 Nonhomologous end-joining 4.25E − 02 −1.19 hsa04070 Phosphatidylinositol signalling system 4.28E − 02 1.06 hsa00190 Oxidative phosphorylation 4.33E − 02 1.08 hsa00730 Thiamine metabolism 4.41E − 02 1.17 hsa03440 Homologous recombination 4.43E − 02 −1.16 hsa00982 Drug metabolism - cytochrome P450 4.55E − 02 1.04 hsa00072 Synthesis and degradation of ketone bodies 4.65E − 02 −1.27 hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate/dermatan sulfate 4.69E − 02 1.15 hsa04360 Axon guidance 4.74E − 02 1.05 hsa00280 Valine, leucine, and isoleucine degradation 4.93E − 02 −1.07 hsa04210 Apoptosis 4.96E − 02 1.06 hsa00300 Lysine biosynthesis 4.99E − 02 −1.47
