Recombinant Klotho Protects Human Periodontal Ligament Stem Cells by Regulating Mitochondrial Function and the Antioxidant System during H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress

<div>Klotho administration ameliorated H<sub>2</sub>O<sub>2</sub>-induced mitochondrial destruction in hPDLSCs. (a) Representative transmission electron microscopy images of mitochondria and their quantification in each group. (b) Flow cytometry and (c) fluorescent microscopy images of the mitochondrial membrane potential in PDLSCs with different treatments. JC-1 aggregates show red fluorescence, indicating high mitochondrial membrane potential, and JC-1 monomers show green fluorescence. M: mitochondria; L: lipid droplet; ER: endoplasmic reticulum. Scale bars: 0.5 <i>μ</i>m (a) or 30 <i>μ</i>m (c). 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Recombinant Klotho Protects Human Periodontal Ligament Stem Cells by Regulating Mitochondrial Function and the Antioxidant System during H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress 

Figure 4 | Recombinant Klotho Protects Human Periodontal Ligament Stem Cells by Regulating Mitochondrial Function and the Antioxidant System during H2O2-Induced Oxidative Stress 