The Research Progress of Host Genes and Tuberculosis Susceptibility

Table 2

Summary of association between the TLR gene and TB susceptibility.

TLR gene	Polymorphic locus	Region	Relationship with TB	References
TLR1	rs4833095 (N248S), rs5743618 (1602S)	Afro-American	Susceptible	[43]
TLR2	rs11938228	Europe, Asia	Susceptible	[44, 45]
		Africa, Spain	Unrelated
		Asia	Unrelated	[46]
	rs5743708	Asia, Caucasians		[47]
TLR4	rs4986790, rs4986791	India	Susceptible	[48]
		Southeast China, Africa	Unrelated	[46, 49]
TLR8	rs3764879, rs3788935, rs3761624, rs3764880	Indonesia, Russia	Susceptible (male)	[50]
TLR9	rs352143, rs5743836	The U.S. (Caucasian, Black)	Susceptible	[50]