Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy

Figure 3

Sal treatment enhanced mitophagy in the MPP⁺/MPTP-induced PD model, and silencing PINK1 inhibited Sal-induced mitophagy. Representative TEM image of mitophagy autophagosomes in MN9D cells (a) and in MN9D cells transfecting with si-PINK1 (b). (c) Representative TEM image of mitophagy autophagosomes in the SN of mice. The arrows indicated mitophagy autophagosomes. Scale bar, 1 μm.

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