Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

Table 3

Selected small molecule activators of NRF2 acting as NRF2-KEAP1 protein-protein interaction inhibitors.

Compound	Type	Ref.	Patent
(SRS)-5	1,2,3,4-Tetrahydroisoquinoline core	[112]	WO2013/067036
Cpd 15	Benzenesulfonyl-pyrimidone	[107]	WO2016/202253
Cpd 16	1,4-Diaminonaphthalene core	[107]	WO2016/202253
Compound 2	1,4-Diaminonaphthalene core	[163]	CN105566241A
3-(Pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one (PSTC)	Sulfonyl coumarins	[164]	WO2015/092713
AN-465/144580	Other structure classes	[165]	JP2011/0167537
Compound 7	Arylcyclohexyl pyrazoles	[166]	WO2017060855