Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway

Figure 5

ECM improves learning and memory in a neurodegenerative mouse model. (a) Escape latency on five consecutive days of testing. (b) The swimming paths of the respective groups on the first and fifth days. (c) The crossing times in the probe trial. (d) Western blot analysis of PSD95 and SYN; β-actin was used as a loading control in the hippocampus. (e) Relative protein levels were quantified by densitometry and normalized to β-actin. Control: vehicle control; ECM-L: (100 mg/kg/d); ECM-M: (200 mg/kg/d); ECM-H: (400 mg/kg/d); vitamin E: (80 mg/kg/d). Data represent ( per group). ^# and ^## in comparison with control group; , , and in comparison with the model group.

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