Dexmedetomidine Attenuates Orthotopic Liver Transplantation-Induced Acute Gut Injury via α₂-Adrenergic Receptor-Dependent Suppression of Oxidative Stress

Figure 3

Blocking α_2A-AR siRNA counteracted the alleviation of oxidative stress by Dex in intestines of rats with OLT. The levels of oxidant ROS (a) and antioxidants including GSTα1 (b), SOD (c), and GSH (d) were measured in rat intestines. Data are represented as the , for each group. S: sham-operated group; M: the model group with OLT; D1: rats that were pretreated with 10 μg/kg before OLT; D2: rats that were pretreated with 50 μg/kg before OLT; B1: rats that received 500 g/kg atipamezole at 40 min before receiving 50 μg/kg Dex prior to OLT; B2: rats that received 50 g/kg ARC239 at 40 min before receiving 50 μg/kg Dex prior to OLT; B3: rats that received 1.5 mg/kg BRL-44408 at 40 min before receiving 50 μg/kg Dex prior to OLT. , compared to Group S; ^#, compared to Group M; , compared to Group D2.

(a)

(b)

(c)

(d)