TRPV1 Contributes to Cerebral Malaria Severity and Mortality by Regulating Brain Inflammation

Figure 5

Activity levels of antioxidant enzymes. (a) Superoxide dismutase (SOD), (b) catalase, (d) glutathione peroxidase (GPx), (e) glutathione reductase (GR), and (f) thioredoxin reductase (TrxR) activity levels in brain samples obtained from TRPV1 wild-type (WT) and knockout (KO) mice infected or not with P. berghei ANKA. (c) Activity levels of catalase in plasma samples of infected TRPV1 WT and KO mice. Samples were collected at stage III/IV or at day 14 for those that survived the observation period. Results represent the of all mice per group, obtained from three independent experiments. is indicated on each graph. Data were analysed by one-way analysis of variance (ANOVA) followed by the Bonferroni test with FDR correction (panels a, b, d, e, and f). Unpaired test was used when appropriate (panel c). differs from noninfected WTs; differs from infected WT mice.

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