Ethyl Acetate Fraction of Lannea microcarpa Engl. and K. Krause (Anacardiaceae) Trunk Barks Corrects Angiotensin II-Induced Hypertension and Endothelial Dysfunction in Mice

Figure 1

Effects of LMAE on systolic and diastolic blood pressure and heart rate in an Ang II-induced hypertension model. LMAE (50 mg/kg) was administered daily by oral gavage for 3 weeks, and osmotic minipumps delivering NaCl (0.9%) or angiotensin II (0.5 mg/kg/day) were implanted 1 week after the start of the LMAE pretreatment. The effect of LMAE was studied in control mice (a, b, and e) and Ang II-treated mice (c, d, and f). Systolic blood pressure (a, c) and diastolic blood pressure (b, d) were measured daily as well as the heart rate (e, f). Angiotensin II (Ang II) treatment induced hypertension that was prevented by LMAE. NaCl: mice treated with NaCl, control; NaCl+LMAE: mice treated with LMAE and NaCl; Ang II: mice treated with Ang II; Ang II+LMAE: mice treated with LMAE and Ang II. NaCl and Ang II groups were treated with an equal volume of vehicle (2% of Tween 80). Results are given as . -8/group; ; ; .

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