Ethyl Acetate Fraction of Lannea microcarpa Engl. and K. Krause (Anacardiaceae) Trunk Barks Corrects Angiotensin II-Induced Hypertension and Endothelial Dysfunction in Mice

Table 1

Effect of LMAE on echocardiography parameters in an Ang II-induced hypertension model.

	NaCl	NaCl+LMAE	Ang II	Ang II+LMAE
Diastolic diameter (mm)
Systolic diameter (mm)
Stroke volume (mL)
Cardiac output (mL/min)
Ejection fraction (%)
Shortening fraction (%)
Diastolic LVAW (mm)
Diastolic LVPW (mm)
Systolic LVAW (mm)
Systolic LVPW (mm)

LMAE (50 mg/kg) was administered daily by oral gavage for 3 weeks, and osmotic minipumps delivering NaCl (0.9%) or angiotensin II (0.5 mg/kg/day) were implanted 1 week after the start of the LMAE pretreatment. Cardiac function was evaluated by echocardiography. This table shows the systolic and diastolic diameters, stroke volume, cardiac output, ejection and fractions, and left ventricle posterior and anterior wall (LVPW, LVAW) thickness in the systolic and diastolic phase. NaCl: mice treated with NaCl, control; NaCl+LMAE: mice treated with LMAE and NaCl; Ang II: mice treated with Ang II; Ang II+LMAE: mice treated with LMAE and Ang II. NaCl and Ang II groups were treated with an equal volume of vehicle (2% of Tween 80). The results are expressed as . /group.