Oxidative Medicine and Cellular Longevity

Review Article

Antiangiogenic Effect of Alkaloids

Table 3

Effects of different alkaloids on angiogenesis.
Name of alkaloidMoleculesBiological resultsSample typeYearAuthor
Noscapine1HIF-1DecreaseInhibit angiogenesis by downregulating VEFGU87MG and T98G cell lines2006Newcomb et al. [97]
2VEGFDecreaseInhibit angiogenesisHuman T98 cell lines2008Newcomb et al. [98]
3VEGFDecreaseInhibit angiogenesisMurine GL261 glioma cell lines2008Newcomb et al. [98]
4MMP-9
VEGF		DecreaseInhibit angiogenesisKBM-5, HL-60, Jurkat, HuT-78, U266, RPMI- 8226, H1299, A293, DU145, and SCC4 cell lines2010Sung et al. [99]
5VEGFDecreaseInhibit angiogenesisThe A549 or H460 cell2010Chougule et al. [100]
6VEGFDecreaseInhibit angiogenesisXenografted with H460 tumors (mice)2010Chougule et al. [100]
7HIFDecreaseInhibit angiogenesisOvarian cancer cells2011Su et al. [101]
8NFKB
VEGF		DecreaseInhibit angiogenesisThe human breast cancer cell lines MDA-MB-231 and MDA-MB-4682011Chougule et al. [100]
Berberine9HIF-1DecreaseInhibit angiogenesis by downregulating VEGFGastric adenocarcinoma cell line SC-M12004Lin et al. [102]
10VEGFDecreaseInhibit angiogenesisHeLa cell2008Lin et al. [103]
11VEGF
MMP-2		DecreaseInhibit angiogenesisHuman umbilical vein endothelial cells2009Gao et al. [104]
12Mmp-2/9
UPA		DecreaseInhibit angiogenesisSquamous cancer cell2009Ho et al. [105]
13VEGFDecreaseInhibit angiogenesisHepatocellular carcinoma2010C. Cheung et al.
14VEGFDecreaseInhibit angiogenesisHep G2 cell line2011Jie et al. [106]
15HIF-1
VEGF		DecreaseInhibit angiogenesisB16F-10 melanoma cells and C57BL/6 mice2012Hamsa and Kuttan [107]
16VEGFDecreaseInhibit angiogenesisXenografted hepatocellular carcinoma (mice)2012Ruhua [108]
17VEGFDecreaseInhibit angiogenesisHepatocellular carcinoma2012Wang et al.
18VEGFDecreaseInhibit angiogenesisBreast cancer2013Kim et al. [109]
19VEGFDecreaseInhibit angiogenesisHepG2 cells2013Wang and Ke [110]
20VEGFDecreaseInhibit angiogenesisHuman non-small-cell lung cancer2013Fu et al. [111]
21Mmp-2
UPA		DecreaseInhibit angiogenesisCervical cancer2014Chu et al.[112]
22VEGFDecreaseInhibit angiogenesisHepatocellular carcinoma2015Tsang et al. [113]
Sanguinarine23VEGFDecreaseInhibit angiogenesisSwine granulosa cell2006Bianco et al. [114]
24VEGFDecreaseInhibit angiogenesisEndothelial cell line2007Basini et al. [115]
25VEGFDecreaseInhibit angiogenesisSwine granulosa cells2007Basini et al. [116]
26VEGFDecreaseInhibit angiogenesisPorcine aortic endothelial cell line2007Basini et al. [117]
27VEGFDecreaseInhibit angiogenesisSwine ovarian follicles2008Basini et al. [116]
28??Inhibit angiogenesisB16 melanoma 4A5 cells2009De Stefano et al. [118]
29VEGFDecreaseInhibit angiogenesisHuman A549 lung cancer cells2013Xu et al. [119]
30VEGFDecreaseInhibit angiogenesisMCF-7 human mammary adenocarcinoma cells2013Dong et al. [120]
31VEGFDecreaseInhibit angiogenesisS180 sarcoma in mice2014Du et al. [121]
32HIF-1DecreaseInhibit angiogenesisPancreatic cancer2015Singh et al. [122]
Sinomenine33VEGFDecreaseInhibit angiogenesisHuman synovial sarcoma cells (Hs701.T)2006Li et al. [123]
34VEGFDecreaseInhibit angiogenesisUmbilical vein endothelial cells (HUVEC) and U2OS cells2016Xie et al. [124]
Taspine35VEGFDecreaseInhibit angiogenesisChicken chorioallantoic membrane (CAM) neovascularization model and CAM transplantation tumor model2008Zhang et al. [125]
36VEGFDecreaseInhibit angiogenesisHuman umbilical vein endothelial cells2008Zhao et al. [126]
37VEGFDecreaseInhibit angiogenesisHuman umbilical vein endothelial cells2010Zhang et al. [127]
38VEGFDecreaseInhibit angiogenesisCaco-2 cell lines2011Zhang et al. [128]
39VEGFDecreaseInhibit angiogenesisHuman liver cancer SMMC77212011Zhang et al. [129]
40VEGFDecreaseInhibit angiogenesisChicken chorioallantoic membrane (CAM) and mouse colon tissue2012Zhang et al. [130]
41VEGFDecreaseInhibit angiogenesisHuman cell lines of SMMC-7721, A549, MCF-7, Lovo, and ECV3042012Zheng et al. [131]
42VEGFDecreaseInhibit angiogenesisA549 cells lung cancer2012Lu et al. [132]
Tetrandrine43PDGFDecreaseInhibit angiogenesisAdjuvant-induced chronic inflammation model of mouse1998Kobayashi et al. [133]
44VEGFDecreaseInhibit angiogenesisRT-2 glioma RT2009Chen et al. [134]
45HIF-1
VEGF		DecreaseInhibit angiogenesisA rat model corneal neovascularization (CNV)2011Sun et al. [135]
46HIF-1
VEGF		DecreaseInhibit angiogenesis4T1 tumor bearing mice2013Gao et al. [136]
47——Inhibit angiogenesisHuman umbilical vein endothelial cells (HUVECs) and the human colon cancer cell line Lovo2013Qian et al. [137]
48——Inhibit angiogenesisLiver cancer xenograft model in nude mice2015Xiao et al. [138]
Brucine49VEGF
TGF-β		DecreaseInhibit angiogenesisMurine cannulated sponge implant angiogenesis model2011Agrawal et al. [139]
50VEGFDecreaseInhibit angiogenesisEhrlich ascites tumor and human cancer cell line2011Agrawal et al. [140]
51VEGFDecreaseInhibit angiogenesisNude mouse model of bone metastasis due to breast cancer2012Li et al. [141]
52HIF-1DecreaseMigration and metastasis and angiogenesisHepatocellular carcinoma2013Shu et al. [142]
53VEGFDecreaseAngiogenesisColon cancer cells2013Luo et al. [143]
54VEGFDecreaseInhibit angiogenesisLovo cell2013Zheng et al. [144]
55VEGFDecreaseInhibit angiogenesisR breast cancer cell line MDA-MB-2312013Kechun and Zjauma [145]
Evodiamine56VEGFDecreaseInhibit angiogenesisHuman lung adenocarcinoma cell (CL1 cells)2006Shyu et al. [146]
57VEGFDecreaseInhibit angiogenesisBreast cancer cell2008Wang et al. [147]
58HIFDecreaseInhibit angiogenesisHuman colon cancer cell2015Huang et al. [148]
Homoharringtonine59VEGFDecreaseInhibit angiogenesisHuman umbilical vein endothelial cell line (ECV304)2004Ye and Lin [149]
60VEGFDecreaseInhibit angiogenesisLeukemic cell line (K562) in vitro2004Ye and Lin [149]
61VEGFDecreaseInhibit angiogenesisMyeloid leukemia cells2005Fei and Zhang [150]
62HIFDecreaseInhibit angiogenesisK562 cell2008Li et al. [151]
Matrine63VEGFDecreaseInhibit angiogenesisBreast cancer cell2009Yu et al. [152]
Halofuginone64VEGF
MMP		DecreaseInhibit angiogenesisBALB/c (nude) mice2003Gross et al. [153]
65——Inhibit angiogenesisMetastatic rat brain tumor model2004Abramovitch et al. [154]
66TGFDecreaseInhibit angiogenesisPolyoma middle T antigen mouse2005Yee et al. [155]
67TGF-β-1, bFGF, COL1A1, MMP-2, MMP-9, VEGF, and PDGFDecreaseInhibit angiogenesisXenografted (rat)2012Jordan and Zeplin [156]
68VEGF
MMP
TGF-β		DecreaseInhibit angiogenesisAcute promyelocytic leukemia mouse model2015Assis et al. [157]
Capsaicine69VEGFDecreaseInhibit angiogenesisEndothelial cells in the rat aorta2008Pyun et al. [158]
70VEGFDecreaseInhibit angiogenesisNon-small-cell lung cancer2014Chakraborty et al. [159]
Pterogynidine71——Inhibit angiogenesisHuman umbilical vein endothelial cells (HUVEC)2009Lopes et al. [160]