Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels
Time course of siramesine and lapatinib-induced cell death. (a) A549 and (b) U87 cells were treated with DMSO (D), lapatinib (L) (0.5 μM), siramesine (S) (10 μM), or the combination of lapatinib+siramesine (L+S) for 1, 2, 4, 6, and 24 hours. Cell death was measured by trypan blue staining and quantified by flow cytometry. Standard error represents three independent experiments (). ns: not significant. Asterisks represent statistical significance: ,, and .
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