Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

<div>Siramesine and the combination with lapatinib induce lysosomal membrane permeabilization (LMP). U87 cells were treated with DMSO, 0.5 <i>μ</i>M lapatinib (Lapa), 10 <i>μ</i>M siramesine (Sira), or the combination of lapatinib+siramesine (L+S). After four hours of treatment, cells were incubated with 50 nM LysoTracker green for 15 min. LMP was related with the loss of fluorescence intensity of each condition when compared with the vehicle control fluorescence intensity. 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Oxidative Medicine and Cellular Longevity

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Figure 6

Figure 6: Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels 

Figure 6 | Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels 