Advanced Glycation End Products: Potential Mechanism and Therapeutic Target in Cardiovascular Complications under Diabetes

Figure 1

Oxidative stress plays an important role in diabetic cardiovascular complications. An impaired balance between oxidization and antioxidant activity in the diabetic cardiovascular system results in more pronounced ROS generation and oxidative stress. Oxidative stress interacts with inflammation and neurohumoral mechanisms, thereby promoting mitochondrial dysfunction, endothelial dysfunction, cardiac fibrosis, and hypertrophy.