Advanced Glycation End Products: Potential Mechanism and Therapeutic Target in Cardiovascular Complications under Diabetes

Figure 3

The interaction between AGE-RAGE axle and oxidative stress plays an important role in diabetic cardiovascular complications. On the one hand, AGE-RAGE axle activation can result in the activation of diverse signal transduction cascades, thereby including the generation of ROS and accelerating oxidative stress. On the other hand, excessive oxidative stress can in turn accelerate the generation of AGEs in the diabetic cardiovascular system.