Advanced Glycation End Products: Potential Mechanism and Therapeutic Target in Cardiovascular Complications under Diabetes

Table 1

Therapeutic candidates against diabetic cardiovascular complications.

Category	Examples	Mechanisms of act
Traditional hypoglycemic agents	Metformin	Antioxidant properties and possible effects on the reduction of AGE
Antioxidants	Vitamin C and vitamin E	Antioxidant properties
	ACEIs and ARBs	Reduce angiotensin II-induced oxidative stress
	Statins	Reduce lipid peroxidation
AGE-RAGE inhibitors	ALT-711	AGE cross-link breaker
	Aminoguanidine	Inhibit AGE formation
	Soluble RAGE	Competitively combine with AGEs
New hypoglycemic agents	GLP-1 receptor agonists	Not fully understood
	DDP-4 inhibitors	Not fully understood
	SGLT-2 inhibitors	Not fully understood