Cerebroprotective Effect against Cerebral Ischemia of the Combined Extract of Oryza sativa and Anethum graveolens in Metabolic Syndrome Rats

Figure 5

Effect of various doses of OA extract on the density of GFAP-positive cell in the cerebral cortex. (a) Immunostaining for GFAP-positive cell in the cerebral cortex. GFAP-positive cell or astrocytes were stained brown (arrow). Magnification, 40x; . (b) GFAP-positive cells in the cerebral cortex. Data are presented as (/group). ^AAA; compared to naïve intact rats, ^BB; compared to sham operation which received HCHF diet and vehicle and all; compared to MCAO rats which received HCHF and vehicle. HCHF: high-carbohydrate high-fat diet; MCAO: right middle cerebral artery occlusion; OA1, OA2, and OA3: the combined extract of O. sativa and A. graveolens at doses of 0.5, 5, and 50 mg/kg BW, respectively. GFAP: glial fibrillary acidic protein.

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