Cerebroprotective Effect against Cerebral Ischemia of the Combined Extract of Oryza sativa and Anethum graveolens in Metabolic Syndrome Rats

Table 1

The effect of various doses of OA extract on oxidative stress markers in the cerebral cortex.

Treatment group	MDA level (ng/mg·protein)	SOD activity (units/mg·protein)	CAT activity (units/mg·protein)	GSH-Px activity (units/mg·protein)
Naïve control
HCHF+sham MCAO+vehicle
HCHF+MCAO+vehicle	^aaa,bbb	^aa,b	^aaa	^aaa
HCHF+MCAO+vitamin C (250 mg/kg BW)
HCHF+MCAO+OA1 (0.5 mg/kg BW)
HCHF+MCAO+OA2 (5 mg/kg BW)
HCHF+MCAO+OA3 (50 mg/kg BW)

Data are presented as (/group). ^aa,aaa, 0.001; compared to naïve intact rats, ^b,bbb, 0.001; compared to sham operation which received HCHF diet and vehicle and , 0.01, and 0.001, respectively; compared to MCAO rats which received HCHF and vehicle. HCHF: high-carbohydrate high-fat diet; MCAO: right middle cerebral artery occlusion; OA1, OA2, and OA3: the combined extract of O. sativa and A. graveolens at doses of 0.5, 5, and 50 mg/kg BW, respectively.