Peroxiredoxin 6 Is a Key Antioxidant Enzyme in Modulating the Link between Glycemic and Lipogenic Metabolism

Table 1

PRDX6^-/- mice develop a proinflammatory state in liver and white adipose tissue. Gene expression analysis obtained by real-time PCR in WT mice and PRDX6^-/- mice for leukocyte cell surface markers (CD68, F4/80, CD11c, CD19, CD3, Arg1, Mgl1, Mgl2, and YM1), chemokines (MCP-1 and Kc), and cytokines (IL-1β, IL-10, TNF-α, IL-6, and IL-21) ( mice per group). All the results were normalized using β-actin and expressed as . a.u.: arbitrary units; ND: not detectable; NS: not significant value. and .

	Adipose tissue			Liver			Skeletal muscle
Gene (a.u.)	WT mice	KO mice	value	WT mice	KO mice	value	WT mice	KO mice	value
IL-β			<0.05			<0.05			NS
IL-10			NS			<0.05			NS
TNF-α			<0.05			<0.05			<0.05
IL-6			<0.05			<0.05			NS
IL-21			NS			NS	ND	ND	ND
Leptin			<0.05	ND	ND	ND	ND	ND	ND
Adiponectin			NS	ND	ND	MD	ND	ND	ND
MCP-1			<0.05			<0.05			<0.05
Kc			NS			<0.05			ND
CD68			<0.05			NS			NS
F4/80			<0.05			<0.05			NS
CD11c			<0.05			<0.05			NS
CD19			<0.05			NS			NS
CD3			NS			<0.05			NS
Arg1			NS			NS			NS
Mgl1			NS			NS			NS
Mgl2			NS			NS			NS
YM1			NS			NS			NS