The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network

Figure 7

The specific inhibition reveals that SOD1 is a regulatory hub in the ROS signaling network that is consisted of the signaling pathways to support growth of cancer cells and to promote cycle arrest and apoptosis of cancer cells. (a) After treating DU145 cells with 50 μM LD100 for 24 h, the main factors leading to cell cycle arrest, mitochondria-dependent apoptosis, and upregulation of antioxidant proteins are summarized. (b) SOD1 is a regulatory hub in the ROS signaling network. Here, red color represents activation or upregulation, and green color represents repression or downregulation.

(a)

(b)