MitoCLox: A Novel Mitochondria-Targeted Fluorescent Probe for Tracing Lipid Peroxidation

Figure 9

Distribution of TLCL and SLPE lipids in MitoCLox-containing monolayer. (a) All frames are aligned according to the plane projection of phenyldiene→TPP⁺ vector, which corresponds to the OY axis in the used coordinate system. For TLCL (orange) and SLPE (green), the areas with average concentration higher than 50% of the lipid concentration in the bilayer are plotted. Distributions of the phenyldiene tail (light green) and TPP (gray) are seen near the zero point. (b) Radial distribution function for dye-lipid distance measured between the phosphorus atom of TPP and C2 glycerol atom of TLCL (orange curve) or SLPE (green curve). This function was calculated over the trajectory of the MitoCLox simulation.

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(b)