Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential

<div>Cardiac inflammation parameters: (a) representative immunoblots of myocardial I<i>κ</i>B<i>α</i>; (b) protein densitometry to Ponceau S of the corresponding samples; (c) quantification of myocardial I<i>κ</i>B<i>α</i>; (d) TNF-<i>α</i> mRNA expression; (e) IL-1<i>β</i> mRNA expression. The means are a consortium of 8 rats 48 h after the surgery. DEF: rats fed the <i>ω</i>3 polyunsaturated fatty acid-deficient diet; EPA: rats fed the eicosapentaenoic acid-enriched diet; Sham: sham-operated rats; Sept: septic rats; <span class="nowrap"><svg height="8.68572pt" id="M146" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 10.095 8.68572" width="10.095pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M743 375C743 570 607 650 407 650H136L130 622C214 612 220 606 204 526L125 122C110 43 105 36 24 27L17 0H250C382 0 482 23 571 76C680 141 743 248 743 375ZM644 379C644 188 520 36 305 36C277 36 249 38 229 46C205 55 202 71 212 126L293 553C300 588 306 600 317 606C330 613 356 617 390 617C547 617 644 537 644 379Z"></path></g></svg>:</span> diet effect; CI: cross-interaction between the effect of the diet and that of sepsis; A, B: histogram bars on the same panel without a common letter are significantly different.</div>

Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential 

Figure 1 | Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential 