Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential

Figure 6

Mitochondrial uncoupling protein-3 (UCP3) (a–c), mitochondrial sirtuin-3 (SIRT3) (d–f), and myocardial voltage-dependent anion channel (VDAC) (g–i) expressions. (a, d, g) Representative immunoblots for UCP3, SIRT3, and VDAC; (b, e, h) protein densitometries to Ponceau S of the corresponding samples; (c, f, i) quantifications of mitochondrial UCP3 and SIRT3 together with myocardial VDAC. The means are the average of 8 rats. DEF: rats fed the ω3 polyunsaturated fatty acid-deficient diet; EPA: rats fed the eicosapentaenoic acid-enriched diet; Sham: sham-operated rats; Sept: septic rats; : diet effect; CI: cross-interaction; A, B: histogram bars on the same panel without a common letter are significantly different.

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