Research Article
Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential
Table 5
Mitochondrial function.
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The means correspond to the average of 8 animals. DEF Sham: animals fed the ω3 fatty acid-deficient diet with the fictitious surgery; DEF Sept: animals fed the ω3 fatty acid-deficient diet with the cecal ligation and puncture; EPA Sham: animals fed the EPA-rich diet with the fictitious surgery; EPA Sept: animals fed the EPA-rich diet with the cecal ligation and puncture; GM: glutamate/malate; SR: succinate/rotenone; PM: palmitoylcarnitine/malate; state 3: state 3 respiration rate (nmoles O2/min/mg of proteins); state 4: state 4 respiration rate (nmoles O2/min/mg of proteins); RCR: respiratory control ratio; ATP: rate of ATP production (nmoles of ATP/min/mg of proteins); ATP : O: ratio between the production of ATP and the state 3 respiration rate (nmoles of ATP/nmoles of O2); ROS state 3 and ROS state 4: H2O2 release during the state 3 and state 4 respirations (pmoles/min/mg of proteins); ROS/state 3: ratio between H2O2 release during state 3 and oxygen consumption during state 3 (pmoles of H2O2/nmoles of O2); ROS/state 4: ratio between H2O2 release during state 4 and oxygen consumption during state 4 (pmoles of H2O2/nmoles of O2); ROS/ATP: ratio between H2O2 release during state 3 and rate of ATP production (pmoles of H2O2/nmole of ATP); a, b, c: means without a common letter for the same parameter are significantly different. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||