Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles

Figure 6

Immunostainings for NOX2 (a), HIF-1α (b), and VEGF-A (c) in retinal cross sections from mice with high IOP (HP) and sham controls (sham). Immunoreactivity to NOX2 was increased in retinal blood vessels and the ganglion cell layer of mice with elevated IOP but did not differ in other retinal layers of both mouse groups. Immunoreactivity to HIF-1α and VEGF-A was similar throughout the retina in both mouse groups. The white arrows point to retinal blood vessel cross sections. GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer. Values are presented as (, ; per group, scale ).

(a)

(b)

(c)