Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathways

Figure 3

Maclurin activated p38 MAPK and inhibited p44/42 MAPK. (a) Maclurin activated p38 mitogen-activated protein kinase (MAPK) and inhibited p44/42 MAPK but not JNK or NF-κB. vs. control group. (b) A Western blot densitometric analysis was performed. (c) SB203580 attenuated the effects of maclurin on p38 MAPK phosphorylation. M: maclurin; PMA: phorbol 12-myristate 13-acetate; SB: SB203580; P-NF-κB: phospho-NF-κB p65 (Ser536); NF-κB: NF-κB p65.

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