Hyperglycemia-Induced Oxidative Stress Abrogates Remifentanil Preconditioning-Mediated Cardioprotection in Diabetic Rats by Impairing Caveolin-3-Modulated PI3K/Akt and JAK2/STAT3 Signaling
RPC improved Cav-3 expression and enhanced Akt and STAT activation in control rats but not in diabetic rats. Control or streptozotocin-induced diabetic rats were subjected to sham operation, myocardial ischemia/reperfusion (I/R), or RPC. (a–d) Representative Western blot of Cav-3 compared with GADPH (a), p-Akt (ser473) compared with total Akt (b), p-STAT3 (Tyr705) (c), and p-STAT3 (Tyr727) (d) compared with total STAT3. All the results are expressed as ,. Differences were analyzed by two-way repeated-measures ANOVA followed by Bonferroni’s post hoc test. and vs. the corresponding sham group; vs. the corresponding I/R group.