Hyperglycemia-Induced Oxidative Stress Abrogates Remifentanil Preconditioning-Mediated Cardioprotection in Diabetic Rats by Impairing Caveolin-3-Modulated PI3K/Akt and JAK2/STAT3 Signaling
Remifentanil treatment attenuated posthypoxic cardiomyocyte injury under LG but not in HG conditions. Isolated rat cardiomyocytes were exposed to low glucose (LG, 5.5 mmol/L) or high glucose (HG, 25 mmol/L) with or without treatment of remifentanil (Remi, 2.5 μM) for 36 h, then subjected to 4 hours of hypoxia followed by 4 hours of reoxygenation (H/R). Cell viability (a) and LDH release (b). All the results are expressed as ,. Differences were analyzed by two-way repeated-measures ANOVA followed by Bonferroni’s post hoc test. vs. the corresponding sham group; vs. the corresponding I/R group.