Oxidative Medicine and Cellular Longevity / 2019 / Article / Tab 2

Research Article

Hyperglycemia-Induced Oxidative Stress Abrogates Remifentanil Preconditioning-Mediated Cardioprotection in Diabetic Rats by Impairing Caveolin-3-Modulated PI3K/Akt and JAK2/STAT3 Signaling

Table 2

Hemodynamics at baseline and after 2 h of reperfusion.

HR (bpm)LVSP (mmHg)+dp/dt (mmHg/s)-dp/dt (mmHg/s)

Baseline (10 min before ischemia)
C
C+RPC
D####
D+RPC####
D+NAC#$$
D+NAC+RPC#$$
After 2 h of reperfusion
C
C+RPC####
D,#,#,#,#
D+RPC,#,#,#,#
D+NAC,$,$,$,$
D+NAC+RPC$,&$,&$,&$&

Control (C), diabetic (D), and N-acetylcysteine-treated diabetic rats (D+NAC, 1.5 g/kg/day) were subjected to myocardial ischemia/reperfusion or remifentanil preconditioning (RPC). The heart rate (HR), left ventricular systolic pressure (LVSP), maximum rate of increase of left ventricular developed pressure (+dp/dt), and maximum rate of decrease of left ventricular developed pressure (-dp/dt) were recorded at 10 min before ischemia (baseline) and 2 h after reperfusion. All the results are expressed as , . Differences in hemodynamics at baseline and after 2 h of reperfusion were analyzed by two-way repeated-measures ANOVA followed by Bonferroni’s post hoc test. vs. their corresponding baseline; vs. their corresponding C group; vs. their corresponding D group; and vs. their corresponding D+NAC group.