Kynurenine, a Tryptophan Metabolite That Increases with Age, Induces Muscle Atrophy and Lipid Peroxidation

<div>Mitochondrial very long-chain acyl-CoA dehydrogenase protein is differentially expressed with KYN or 1-MT treatment of female mice <i>in vivo</i> and human myoblasts <i>in vitro.</i> (a) Proteomics run on quadriceps muscle homogenates from young mice treated with KYN or aged mice treated with 1-MT showed that VLCADm was significantly increased with KYN treatment in young mice. (b) Representative western blots from primary human cells that showed a significant increase in VLCADm with KYN treatment. (c) VLCADm western blot results were normalized to <i>β</i>-actin controls and quantified. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Kynurenine, a Tryptophan Metabolite That Increases with Age, Induces Muscle Atrophy and Lipid Peroxidation 