Evaluation of Binding of Rosmarinic Acid with Human Transferrin and Its Impact on the Protein Structure: Targeting Polyphenolic Acid-Induced Protection of Neurodegenerative Disorders

Figure 2

(a) Cartoon representation of hTf in a complex with RA. Three-dimensional view of binding pocket residues of hTf interacting with RA. Polar interactions sharing residues are shown in the sticks (zoomed view). (b) Interpolated charged surface view of hTf binding pocket occupied by RA (the shaded red areas correspond to negatively charged residues and the blue areas to positively charged residues). (c) Two-dimensional diagram of hTf residues interacting with RA.

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