Evaluation of Binding of Rosmarinic Acid with Human Transferrin and Its Impact on the Protein Structure: Targeting Polyphenolic Acid-Induced Protection of Neurodegenerative Disorders

Figure 5

(a) Plot highlighting the changes in the computed distance between the hTf and RA. (b) Hydrogen bond fluctuation curve highlighting the changes in the observed number. (c) The curves showing the difference in the compactness between the RA bound and unbound hTf. (d) The RMSD plots highlighting the changes between the stabilities in the observed systems. (e) The graphical representation of the changes observed in the fluctuation of the constituent residues between the RA bound and unbound hTf. (f) The 2-D eigenvector projection plot showing the differences between the flexibility of the two studied forms.

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