Cardiolipin, Perhydroxyl Radicals, and Lipid Peroxidation in Mitochondrial Dysfunctions and Aging

<div>Cardiolipin structure. The figure depicts (for simplicity only) one of the cardiolipins–tetraoleilcardiolipin, and the two models headgroup ionization state at physiological pH 7.2. (a) Both phosphates have values of pK<sub>a1</sub> of orthophosphoric acid. It is assumed that both phosphates ionize independently and the headgroup exists as a dianion. (b) Disparate pKa values of the two phosphates presume that the headgroup exists as a monoanion. The figure was adapted from [<a href="/journals/omcl/2020/1323028/#B27">27</a>]. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Cardiolipin, Perhydroxyl Radicals, and Lipid Peroxidation in Mitochondrial Dysfunctions and Aging 