Zinc Oxide Nanoparticle Synergizes Sorafenib Anticancer Efficacy with Minimizing Its Cytotoxicity

Table 2

Hematological and biochemical parameters. Values are expressed as of 10 animals in each group.

Parameters	Control	SEC	MTX	ZnO-NPs	Sorafenib	ZnO-NPs+sorafenib
Hematological parameters
HB (g/L)		^a					<0.001
Leucocytes ()		^a	^b	^b	^b	^b,d	<0.001
RBCs (/mm^3)							<0.001
Renal parameters
Urea (mmol/L)		^a	^b	^c		^b,d	<0.001
Creatinine (mmol/L)		^a	^b	^b	^a,b	^b,e	<0.001
Hepatic parameters
ALT (U/L)		^a	^b	^b,c	^a,c	^b,e	<0.001
AST (U/L)		^a	^a,b	^a,b	^a,b	^a,b,c	<0.001

SD: standard deviation; : probability; ; high significance. The test used one-way ANOVA followed by post hoc Tukey. ^aSignificant compared to the control group. ^bSignificant compared to the control SEC group. ^cSignificant compared to the MTX group. ^dSignificant compared to the ZnO-NP group. ^eSignificant compared to the sorafenib group.