Reactive Oxygen Species Induce Endothelial Differentiation of Liver Cancer Stem-Like Sphere Cells through the Activation of Akt/IKK Signaling Pathway

<div>Effects of various signaling pathway inhibitors on the tube formation of HMEC-1 or endothelial differentiated sphere cells on Matrigel. HMEC-1 or endothelial differentiated sphere cells seeded on Matrigel were treated with or without indicated concentrations of Bevacizumab (a), DAPT (b), Akt1/2 kinase inhibitor (c), or BAY 11-7082 (d) for 24 h. The photographs of tube formation were taken (100×). The number of formed tubes was calculated. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Reactive Oxygen Species Induce Endothelial Differentiation of Liver Cancer Stem-Like Sphere Cells through the Activation of Akt/IKK Signaling Pathway 

Figure 3 | Reactive Oxygen Species Induce Endothelial Differentiation of Liver Cancer Stem-Like Sphere Cells through the Activation of Akt/IKK Signaling Pathway 